Epigenetic Regulation of the N-Terminal Truncated Isoform of Matrix Metalloproteinase-2 (NTT-MMP-2) and Its Presence in Renal and Cardiac Diseases

Several clinical and experimental studies have documented a compelling and critical role for the full-length matrix metalloproteinase-2 (FL-MMP-2) in ischemic renal injury, progressive renal fibrosis, and diabetic nephropathy. A novel N-terminal truncated isoform of MMP-2 (NTT-MMP-2) was recently di...

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Principais autores:	Juliana de Oliveira Cruz, Alessandra O. Silva, Jessyca M. Ribeiro, Marcelo R. Luizon, Carla S. Ceron
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2021-02-01
Colecção:	Frontiers in Genetics
Assuntos:	acute kidney injury alternative promoter chronic kidney disease histone modifications matrix metalloproteinase-2 mitochondria
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fgene.2021.637148/full
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