Cardiomyocyte‐enriched OTUD5 alleviates septic cardiomyopathy by promoting NLRP3 deubiquitination and inhibiting NLRP3 inflammasome activation

Abstract Background Septic cardiomyopathy (SCM) is the leading cause of mortality among patients diagnosed with sepsis. Nevertheless, the precise mechanisms underlying its pathogenesis remain poorly understood. Deubiquitinating enzymes (DUBs) play a vital role in various cardiovascular diseases. Met...

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Autori principali:	Yucheng Jiang, Zhihan Jia, Zhaozheng Zheng, Yingjie Liao, Qingqing Zhao, Wante Lin, Diyun Xu, Naijin Zhang, Guang Liang, Bozhi Ye
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Wiley 2026-07-01
Serie:	Clinical and Translational Medicine
Soggetti:	deubiquitinating enzyme NLRP3 OTUD5 pyroptosis septic cardiomyopathy
Accesso online:	https://doi.org/10.1002/ctm2.70743
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