Cardiomyocyte‐enriched OTUD5 alleviates septic cardiomyopathy by promoting NLRP3 deubiquitination and inhibiting NLRP3 inflammasome activation

Abstract Background Septic cardiomyopathy (SCM) is the leading cause of mortality among patients diagnosed with sepsis. Nevertheless, the precise mechanisms underlying its pathogenesis remain poorly understood. Deubiquitinating enzymes (DUBs) play a vital role in various cardiovascular diseases. Met...

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Автори:	Yucheng Jiang, Zhihan Jia, Zhaozheng Zheng, Yingjie Liao, Qingqing Zhao, Wante Lin, Diyun Xu, Naijin Zhang, Guang Liang, Bozhi Ye
Формат:	Artigo
Мова:	Inglês
Опубліковано:	Wiley 2026-07-01
Серія:	Clinical and Translational Medicine
Предмети:	deubiquitinating enzyme NLRP3 OTUD5 pyroptosis septic cardiomyopathy
Онлайн доступ:	https://doi.org/10.1002/ctm2.70743
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