Cardiomyocyte‐enriched OTUD5 alleviates septic cardiomyopathy by promoting NLRP3 deubiquitination and inhibiting NLRP3 inflammasome activation

Abstract Background Septic cardiomyopathy (SCM) is the leading cause of mortality among patients diagnosed with sepsis. Nevertheless, the precise mechanisms underlying its pathogenesis remain poorly understood. Deubiquitinating enzymes (DUBs) play a vital role in various cardiovascular diseases. Met...

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Autores principales:	Yucheng Jiang, Zhihan Jia, Zhaozheng Zheng, Yingjie Liao, Qingqing Zhao, Wante Lin, Diyun Xu, Naijin Zhang, Guang Liang, Bozhi Ye
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Wiley 2026-07-01
Colección:	Clinical and Translational Medicine
Materias:	deubiquitinating enzyme NLRP3 OTUD5 pyroptosis septic cardiomyopathy
Acceso en línea:	https://doi.org/10.1002/ctm2.70743
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!