Continuous transport of a small fraction of plasma membrane cholesterol to endoplasmic reticulum regulates total cellular cholesterol

Cells employ regulated transport mechanisms to ensure that their plasma membranes (PMs) are optimally supplied with cholesterol derived from uptake of low-density lipoproteins (LDL) and synthesis. To date, all inhibitors of cholesterol transport block steps in lysosomes, limiting our understanding o...

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Ngā kaituhi matua:	Rodney Elwood Infante, Arun Radhakrishnan
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	eLife Sciences Publications Ltd 2017-04-01
Rangatū:	eLife
Ngā marau:	cholesterol transport plasma membrane endoplasmic reticulum Niemann Pick C lysosomes cholesterol-binding toxin
Urunga tuihono:	https://elifesciences.org/articles/25466
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!