Continuous transport of a small fraction of plasma membrane cholesterol to endoplasmic reticulum regulates total cellular cholesterol

Cells employ regulated transport mechanisms to ensure that their plasma membranes (PMs) are optimally supplied with cholesterol derived from uptake of low-density lipoproteins (LDL) and synthesis. To date, all inhibitors of cholesterol transport block steps in lysosomes, limiting our understanding o...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Rodney Elwood Infante, Arun Radhakrishnan
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	eLife Sciences Publications Ltd 2017-04-01
Schriftenreihe:	eLife
Schlagworte:	cholesterol transport plasma membrane endoplasmic reticulum Niemann Pick C lysosomes cholesterol-binding toxin
Online-Zugang:	https://elifesciences.org/articles/25466
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