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Continuous transport of a small fraction of plasma membrane cholesterol to endoplasmic reticulum regulates total cellular cholesterol

Cells employ regulated transport mechanisms to ensure that their plasma membranes (PMs) are optimally supplied with cholesterol derived from uptake of low-density lipoproteins (LDL) and synthesis. To date, all inhibitors of cholesterol transport block steps in lysosomes, limiting our understanding o...

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書誌詳細
主要な著者: Rodney Elwood Infante, Arun Radhakrishnan
フォーマット: Artigo
言語:Inglês
出版事項: eLife Sciences Publications Ltd 2017-04-01
シリーズ:eLife
主題:
オンライン・アクセス:https://elifesciences.org/articles/25466
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