Continuous transport of a small fraction of plasma membrane cholesterol to endoplasmic reticulum regulates total cellular cholesterol

Cells employ regulated transport mechanisms to ensure that their plasma membranes (PMs) are optimally supplied with cholesterol derived from uptake of low-density lipoproteins (LDL) and synthesis. To date, all inhibitors of cholesterol transport block steps in lysosomes, limiting our understanding o...

Celý popis

Podrobná bibliografie

Hlavní autoři:	Rodney Elwood Infante, Arun Radhakrishnan
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	eLife Sciences Publications Ltd 2017-04-01
Edice:	eLife
Témata:	cholesterol transport plasma membrane endoplasmic reticulum Niemann Pick C lysosomes cholesterol-binding toxin
On-line přístup:	https://elifesciences.org/articles/25466
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!