Proapoptotic BIM Impacts B Lymphoid Homeostasis by Limiting the Survival of Mature B Cells in a Cell-Autonomous Manner

The proapoptotic BH3-only protein BIM (Bcl2l11) plays key roles in the maintenance of multiple hematopoietic cell types. In mice, germline knockout or conditional pan-hematopoietic deletion of Bim results in marked splenomegaly and significantly increased numbers of B cells. However, it has remained...

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Detalhes bibliográficos

Principais autores:	Rui Liu, Ashleigh King, Philippe Bouillet, David M. Tarlinton, Andreas Strasser, Jörg Heierhorst
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2018-03-01
coleção:	Frontiers in Immunology
Assuntos:	apoptosis cell death BCL-2 family BIM BH3-only protein B lymphocytes
Acesso em linha:	http://journal.frontiersin.org/article/10.3389/fimmu.2018.00592/full
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