Proapoptotic BIM Impacts B Lymphoid Homeostasis by Limiting the Survival of Mature B Cells in a Cell-Autonomous Manner

The proapoptotic BH3-only protein BIM (Bcl2l11) plays key roles in the maintenance of multiple hematopoietic cell types. In mice, germline knockout or conditional pan-hematopoietic deletion of Bim results in marked splenomegaly and significantly increased numbers of B cells. However, it has remained...

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Auteurs principaux:	Rui Liu, Ashleigh King, Philippe Bouillet, David M. Tarlinton, Andreas Strasser, Jörg Heierhorst
Format:	Artigo
Langue:	Inglês
Publié:	Frontiers Media S.A. 2018-03-01
Collection:	Frontiers in Immunology
Sujets:	apoptosis cell death BCL-2 family BIM BH3-only protein B lymphocytes
Accès en ligne:	http://journal.frontiersin.org/article/10.3389/fimmu.2018.00592/full
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