Requirement for PLK1 kinase activity in the maintenance of a robust spindle assembly checkpoint
During mitotic arrest induced by microtubule targeting drugs, the weakening of the spindle assembly checkpoint (SAC) allows cells to progress through the cell cycle without chromosome segregation occurring. PLK1 kinase plays a major role in mitosis and emerging evidence indicates that PLK1 is also i...
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| Principais autores: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Company of Biologists
2016-01-01
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| coleção: | Biology Open |
| Assuntos: | |
| Acesso em linha: | http://bio.biologists.org/content/5/1/11 |
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