Requirement for PLK1 kinase activity in the maintenance of a robust spindle assembly checkpoint

During mitotic arrest induced by microtubule targeting drugs, the weakening of the spindle assembly checkpoint (SAC) allows cells to progress through the cell cycle without chromosome segregation occurring. PLK1 kinase plays a major role in mitosis and emerging evidence indicates that PLK1 is also i...

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Autors principals:	Aisling O'Connor, Stefano Maffini, Michael D. Rainey, Agnieszka Kaczmarczyk, David Gaboriau, Andrea Musacchio, Corrado Santocanale
Format:	Artigo
Idioma:	Inglês
Publicat:	The Company of Biologists 2016-01-01
Col·lecció:	Biology Open
Matèries:	Cell-Cycle PLK1 Aurora B MPS1, Haspin, Spindle assembly checkpoint Kinase inhibitors
Accés en línia:	http://bio.biologists.org/content/5/1/11
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