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A molecular basis for the differential roles of Bub1 and BubR1 in the spindle assembly checkpoint

The spindle assembly checkpoint (SAC) monitors and promotes kinetochore–microtubule attachment during mitosis. Bub1 and BubR1, SAC components, originated from duplication of an ancestor gene. Subsequent sub-functionalization established subordination: Bub1, recruited first to kinetochores, promotes...

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Principais autores: Katharina Overlack, Ivana Primorac, Mathijs Vleugel, Veronica Krenn, Stefano Maffini, Ingrid Hoffmann, Geert J P L Kops, Andrea Musacchio
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications Ltd 2015-01-01
coleção:eLife
Assuntos:
cell division
centromere
kinetochore
spindle assembly checkpoint
cell cycle
Acesso em linha:https://elifesciences.org/articles/05269
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