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Requirement for PLK1 kinase activity in the maintenance of a robust spindle assembly checkpoint

During mitotic arrest induced by microtubule targeting drugs, the weakening of the spindle assembly checkpoint (SAC) allows cells to progress through the cell cycle without chromosome segregation occurring. PLK1 kinase plays a major role in mitosis and emerging evidence indicates that PLK1 is also i...

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Автори: Aisling O'Connor, Stefano Maffini, Michael D. Rainey, Agnieszka Kaczmarczyk, David Gaboriau, Andrea Musacchio, Corrado Santocanale
Формат: Artigo
Мова:Inglês
Опубліковано: The Company of Biologists 2016-01-01
Серія:Biology Open
Предмети:
Cell-Cycle
PLK1
Aurora B
MPS1, Haspin, Spindle assembly checkpoint
Kinase inhibitors
Онлайн доступ:http://bio.biologists.org/content/5/1/11
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