The dispensability of VH-VL pairing and the indispensability of VL domain integrity in the IgG1 secretion process

Introduction: The CH1 domain of IgG antibodies controls assembly and secretion, mediated by the molecular chaperone BiP via the endoplasmic reticulum protein quality control (ERQC) mechanism. However, it is not clear whether the variable domains are necessary for this process.Methods: Here, we gener...

पूर्ण विवरण

ग्रंथसूची विवरण

मुख्य लेखकों:	Juho Choi, Yerin Jeon, Youngin Roh, Jeongyun Jang, Eunbin Lee, Luigie Villamante, Minjae Kim, Myung-Hee Kwon
स्वरूप:	Artigo
भाषा:	Inglês
प्रकाशित:	Frontiers Media S.A. 2024-05-01
श्रृंखला:	Frontiers in Molecular Biosciences
विषय:	IgG assembly secretion endoplasmic reticulum quality control VH domain VL domain
ऑनलाइन पहुंच:	https://www.frontiersin.org/articles/10.3389/fmolb.2024.1346259/full
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