The dispensability of VH-VL pairing and the indispensability of VL domain integrity in the IgG1 secretion process
Introduction: The CH1 domain of IgG antibodies controls assembly and secretion, mediated by the molecular chaperone BiP via the endoplasmic reticulum protein quality control (ERQC) mechanism. However, it is not clear whether the variable domains are necessary for this process.Methods: Here, we gener...
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| Автори: | , , , , , , , |
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| Формат: | Artigo |
| Мова: | Inglês |
| Опубліковано: |
Frontiers Media S.A.
2024-05-01
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| Серія: | Frontiers in Molecular Biosciences |
| Предмети: | |
| Онлайн доступ: | https://www.frontiersin.org/articles/10.3389/fmolb.2024.1346259/full |
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