The dispensability of VH-VL pairing and the indispensability of VL domain integrity in the IgG1 secretion process

Introduction: The CH1 domain of IgG antibodies controls assembly and secretion, mediated by the molecular chaperone BiP via the endoplasmic reticulum protein quality control (ERQC) mechanism. However, it is not clear whether the variable domains are necessary for this process.Methods: Here, we gener...

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Hauptverfasser:	Juho Choi, Yerin Jeon, Youngin Roh, Jeongyun Jang, Eunbin Lee, Luigie Villamante, Minjae Kim, Myung-Hee Kwon
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2024-05-01
Schriftenreihe:	Frontiers in Molecular Biosciences
Schlagworte:	IgG assembly secretion endoplasmic reticulum quality control VH domain VL domain
Online-Zugang:	https://www.frontiersin.org/articles/10.3389/fmolb.2024.1346259/full
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