The dispensability of VH-VL pairing and the indispensability of VL domain integrity in the IgG1 secretion process

Introduction: The CH1 domain of IgG antibodies controls assembly and secretion, mediated by the molecular chaperone BiP via the endoplasmic reticulum protein quality control (ERQC) mechanism. However, it is not clear whether the variable domains are necessary for this process.Methods: Here, we gener...

Celý popis

Podrobná bibliografie

Hlavní autoři:	Juho Choi, Yerin Jeon, Youngin Roh, Jeongyun Jang, Eunbin Lee, Luigie Villamante, Minjae Kim, Myung-Hee Kwon
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2024-05-01
Edice:	Frontiers in Molecular Biosciences
Témata:	IgG assembly secretion endoplasmic reticulum quality control VH domain VL domain
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fmolb.2024.1346259/full
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!