The dispensability of VH-VL pairing and the indispensability of VL domain integrity in the IgG1 secretion process

Introduction: The CH1 domain of IgG antibodies controls assembly and secretion, mediated by the molecular chaperone BiP via the endoplasmic reticulum protein quality control (ERQC) mechanism. However, it is not clear whether the variable domains are necessary for this process.Methods: Here, we gener...

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Principais autores:	Juho Choi, Yerin Jeon, Youngin Roh, Jeongyun Jang, Eunbin Lee, Luigie Villamante, Minjae Kim, Myung-Hee Kwon
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2024-05-01
coleção:	Frontiers in Molecular Biosciences
Assuntos:	IgG assembly secretion endoplasmic reticulum quality control VH domain VL domain
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fmolb.2024.1346259/full
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