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Effect of endothelium on the anticoagulant activity of a covalent antithrombin-heparin complex

Abstract We developed a covalent antithrombin-heparin complex (ATH) with superior In vivo anticoagulant efficacy compared to non-covalent antithrombin (AT) + unfractionated heparin (H). Previous in vitro studies of ATH, investigating the mechanisms behind its efficacy, were done in the absence of en...

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Autors principals: Helen M. Atkinson, Ivan Stevic, Leslie R. Berry, Anthony K. C. Chan
Format: Artigo
Idioma:Inglês
Publicat: Nature Portfolio 2024-09-01
Col·lecció:Scientific Reports
Accés en línia:https://doi.org/10.1038/s41598-024-72458-0
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