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Cleavage of the antithrombin III binding site in heparin by heparinases and its implication in the generation of low molecular weight heparin

Heparin has been used as a clinical anticoagulant for more than 50 years, making it one of the most effective pharmacological agents known. Much of heparin's activity can be traced to its ability to bind antithrombin III (AT-III). Low molecular weight heparin (LMWH), derived from heparin by its...

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Bibliografski detalji
Glavni autori: Shriver, Zachary, Sundaram, Mallikarjun, Venkataraman, Ganesh, Fareed, Jawed, Linhardt, Robert, Biemann, Klaus, Sasisekharan, Ram
Format: Artigo
Jezik:Inglês
Izdano: The National Academy of Sciences 2000
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC27030/
https://ncbi.nlm.nih.gov/pubmed/10984532
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