Cleavage of the antithrombin III binding site in heparin by heparinases and its implication in the generation of low molecular weight heparin

Heparin has been used as a clinical anticoagulant for more than 50 years, making it one of the most effective pharmacological agents known. Much of heparin's activity can be traced to its ability to bind antithrombin III (AT-III). Low molecular weight heparin (LMWH), derived from heparin by its cont...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Shriver, Zachary, Sundaram, Mallikarjun, Venkataraman, Ganesh, Fareed, Jawed, Linhardt, Robert, Biemann, Klaus, Sasisekharan, Ram
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2000
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC27030/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10984532/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.97.19.10365
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