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Rac1 and Cdc42 are regulators of HRas<sup>V12</sup>-transformation and angiogenic factors in human fibroblasts

<p>Abstract</p> <p>Background</p> <p>The activities of Rac1 and Cdc42 are essential for HRas-induced transformation of rodent fibroblasts. What is more, expression of constitutively activated mutants of Rac1 and/or Cdc42 is sufficient for their malignant transformation. The role for these two Rho GT...

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Bibliografiset tiedot
Päätekijät: Dao Kim-Hien T, Appledorn Daniel M, O'Reilly Sandra, Maher Veronica M, McCormick J Justin
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: BMC 2010-01-01
Sarja:BMC Cancer
Linkit:http://www.biomedcentral.com/1471-2407/10/13
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