Partial reversion of the transformed phenotype in HRAS-transfected tumorigenic cells by transfer of a human gene.

The transformed phenotype of rat FE-8 cells transfected by an activated human HRAS gene was suppressed upon fusion with normal cells. An experimental approach was developed to identify and isolate a human gene capable of suppressing the transforming activity of the HRAS oncogene in FE-8 cells. Genom...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Schaefer, R, Iyer, J, Iten, E, Nirkko, A C
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 1988
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC279819/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3125552/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.85.5.1590
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