Mapping essential somatic hypermutations in a CD4-binding site bNAb informs HIV-1 vaccine design

Summary: HIV-1 broadly neutralizing antibodies (bNAbs) targeting the CD4-binding site (CD4bs) contain rare features that pose challenges to elicit these bNAbs through vaccination. The IOMA class of CD4bs bNAbs includes fewer rare features and somatic hypermutations (SHMs) to achieve broad neutraliza...

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Principais autores:	Kim-Marie A. Dam, Harry B. Gristick, Yancheng E. Li, Zhi Yang, Priyanthi N.P. Gnanapragasam, Anthony P. West, Jr., Michael S. Seaman, Pamela J. Bjorkman
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2025-05-01
coleção:	Cell Reports
Assuntos:	CP: Immunology CP: Microbiology
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S221112472500484X
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