Mapping essential somatic hypermutations in a CD4-binding site bNAb informs HIV-1 vaccine design

Summary: HIV-1 broadly neutralizing antibodies (bNAbs) targeting the CD4-binding site (CD4bs) contain rare features that pose challenges to elicit these bNAbs through vaccination. The IOMA class of CD4bs bNAbs includes fewer rare features and somatic hypermutations (SHMs) to achieve broad neutraliza...

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Hlavní autoři:	Kim-Marie A. Dam, Harry B. Gristick, Yancheng E. Li, Zhi Yang, Priyanthi N.P. Gnanapragasam, Anthony P. West, Jr., Michael S. Seaman, Pamela J. Bjorkman
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2025-05-01
Edice:	Cell Reports
Témata:	CP: Immunology CP: Microbiology
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S221112472500484X
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