Histone H2A-Reactive B Cells Are Functionally Anergic in Healthy Mice With Potential to Provide Humoral Protection Against HIV-1

Peripheral tolerance is essential for silencing weakly autoreactive B cells that have escaped central tolerance, but it is unclear why these potentially pathogenic B cells are retained rather than being eliminated entirely. Release from peripheral tolerance restraint can occur under certain circumst...

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Bibliografische gegevens

Hoofdauteurs:	Amanda Agazio, Jennifer Cimons, Kristin M. Shotts, Kejun Guo, Mario L. Santiago, Roberta Pelanda, Raul M. Torres
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	Frontiers Media S.A. 2020-07-01
Reeks:	Frontiers in Immunology
Onderwerpen:	B cells peripheral tolerance autoreactive polyreactive HIV-1 bnAbs
Online toegang:	https://www.frontiersin.org/article/10.3389/fimmu.2020.01565/full
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