Histone H2A-Reactive B Cells Are Functionally Anergic in Healthy Mice With Potential to Provide Humoral Protection Against HIV-1

Peripheral tolerance is essential for silencing weakly autoreactive B cells that have escaped central tolerance, but it is unclear why these potentially pathogenic B cells are retained rather than being eliminated entirely. Release from peripheral tolerance restraint can occur under certain circumst...

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Detalles Bibliográficos

Principais autores:	Amanda Agazio, Jennifer Cimons, Kristin M. Shotts, Kejun Guo, Mario L. Santiago, Roberta Pelanda, Raul M. Torres
Formato:	Artigo
Idioma:	Inglês
Publicado:	Frontiers Media S.A. 2020-07-01
Series:	Frontiers in Immunology
Assuntos:	B cells peripheral tolerance autoreactive polyreactive HIV-1 bnAbs
Acceso en liña:	https://www.frontiersin.org/article/10.3389/fimmu.2020.01565/full
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