Production of Autoreactive Heavy Chain-Only Antibodies in Systemic Lupus Erythematosus

Systemic lupus erythematosus (SLE) is characterized by the overproduction of high-affinity autoreactive antibodies. Here, we show that more than 65.8% of 222 recombinant antibodies derived from 8 SLE patients can be secreted as heavy chain-only antibodies (HCAbs) when expressed in HEK-293T cells. Th...

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Detalhes bibliográficos

Principais autores:	Shu Xu, Hong Yang, Yue Zhuo, Yangsheng Yu, Hongyan Liao, Song Li, Yinshi Yue, Kaihong Su, Zhixin Zhang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2020-05-01
coleção:	Frontiers in Immunology
Assuntos:	B cell plasmablast heavy chain antibody polyreactive antibody autoreactive antibody somatic hypermutation
Acesso em linha:	https://www.frontiersin.org/article/10.3389/fimmu.2020.00632/full
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