Production of Autoreactive Heavy Chain-Only Antibodies in Systemic Lupus Erythematosus

Systemic lupus erythematosus (SLE) is characterized by the overproduction of high-affinity autoreactive antibodies. Here, we show that more than 65.8% of 222 recombinant antibodies derived from 8 SLE patients can be secreted as heavy chain-only antibodies (HCAbs) when expressed in HEK-293T cells. Th...

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Bibliographic Details

Main Authors:	Shu Xu, Hong Yang, Yue Zhuo, Yangsheng Yu, Hongyan Liao, Song Li, Yinshi Yue, Kaihong Su, Zhixin Zhang
Format:	Artigo
Language:	Inglês
Published:	Frontiers Media S.A. 2020-05-01
Series:	Frontiers in Immunology
Subjects:	B cell plasmablast heavy chain antibody polyreactive antibody autoreactive antibody somatic hypermutation
Online Access:	https://www.frontiersin.org/article/10.3389/fimmu.2020.00632/full
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