Mapping essential somatic hypermutations in a CD4-binding site bNAb informs HIV-1 vaccine design

Summary: HIV-1 broadly neutralizing antibodies (bNAbs) targeting the CD4-binding site (CD4bs) contain rare features that pose challenges to elicit these bNAbs through vaccination. The IOMA class of CD4bs bNAbs includes fewer rare features and somatic hypermutations (SHMs) to achieve broad neutraliza...

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Үндсэн зохиолчид:	Kim-Marie A. Dam, Harry B. Gristick, Yancheng E. Li, Zhi Yang, Priyanthi N.P. Gnanapragasam, Anthony P. West, Jr., Michael S. Seaman, Pamela J. Bjorkman
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Elsevier 2025-05-01
Цуврал:	Cell Reports
Нөхцлүүд:	CP: Immunology CP: Microbiology
Онлайн хандалт:	http://www.sciencedirect.com/science/article/pii/S221112472500484X
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!