Overexpression of Vesicular Monoamine Transporter-2 may Block Neurotoxic Metabolites from Cytosolic Dopamine: a Potential Neuroprotective Therapy for Parkinson’s Disease

af Segura-Aguilar, Sulzer, David, Zucca, Fabio A., Zecca, Luigi
Udgivet i Clin Pharmacol Transl Med (2019)

Norepinephrine and its metabolites are involved in the synthesis of neuromelanin derived from the locus coeruleus

af Wakamatsu, Kazumasa, Tabuchi, Keisuke, Ojika, Makoto, Zucca, Fabio A., Zecca, Luigi, Ito, Shosuke
Udgivet i J Neurochem (2015)

Interaction of Neuromelanin with Xenobiotics and Consequences for Neurodegeneration; Promising Experimental Models

af Capucciati, Andrea, Zucca, Fabio A., Monzani, Enrico, Zecca, Luigi, Casella, Luigi, Hofer, Tim
Udgivet i Antioxidants (Basel) (2021)

The role of iron in brain ageing and neurodegenerative disorders

af Ward, Roberta J, Zucca, Fabio A, Duyn, Jeff H, Crichton, Robert R, Zecca, Luigi
Udgivet i Lancet Neurol (2014)

Neuronal pigmented autophagic vacuoles: lipofuscin, neuromelanin, and ceroid as macroautophagic responses during aging and disease

af Sulzer, David, Mosharov, Eugene, Talloczy, Zsolt, Zucca, Fabio A., Simon, John D., Zecca, Luigi
Udgivet i J Neurochem (2008)

The protective and toxic role of neuromelanins in brain aging and Parkinson’s disease

af Zecca, Luigi, Bellei, Chiara, Mauri, Pierluigi, Casella, Luigi, Cebrián, Carolina, Sulzer, David, Zucca, Fabio A
Udgivet i Springerplus (2015)

Reduction of the Nitro Group to Amine by Hydroiodic Acid to Synthesize o-Aminophenol Derivatives as Putative Degradative Markers of Neuromelanin

af Wakamatsu, Kazumasa, Tanaka, Hitomi, Tabuchi, Keisuke, Ojika, Makoto, Zucca, Fabio A., Zecca, Luigi, Ito, Shosuke
Udgivet i Molecules (2014)

Neuromelanins of Human Brain Have Soluble and Insoluble Components with Dolichols Attached to the Melanic Structure

af Engelen, Mireille, Vanna, Renzo, Bellei, Chiara, Zucca, Fabio A., Wakamatsu, Kazumasa, Monzani, Enrico, Ito, Shosuke, Casella, Luigi, Zecca, Luigi
Udgivet 2012

The surface oxidation potential of human neuromelanin reveals a spherical architecture with a pheomelanin core and a eumelanin surface

af Bush, William D., Garguilo, Jacob, Zucca, Fabio A., Albertini, Alberto, Zecca, Luigi, Edwards, Glenn S., Nemanich, Robert J., Simon, John D.
Udgivet 2006

INTERACTIONS OF IRON, DOPAMINE AND NEUROMELANIN PATHWAYS IN BRAIN AGING AND PARKINSON'S DISEASE

af Zucca, Fabio A., Segura-Aguilar, Juan, Ferrari, Emanuele, Muñoz, Patricia, Paris, Irmgard, Sulzer, David, Sarna, Tadeusz, Casella, Luigi, Zecca, Luigi
Udgivet i Prog Neurobiol (2015)

Neuromelanin detection by magnetic resonance imaging (MRI) and its promise as a biomarker for Parkinson’s disease

af Sulzer, David, Cassidy, Clifford, Horga, Guillermo, Kang, Un Jung, Fahn, Stanley, Casella, Luigi, Pezzoli, Gianni, Langley, Jason, Hu, Xiaoping P., Zucca, Fabio A., Isaias, Ioannis U., Zecca, Luigi
Udgivet i NPJ Parkinsons Dis (2018)

Neuromelanin organelles are specialized autolysosomes that accumulate undegraded proteins and lipids in aging human brain and are likely involved in Parkinson’s disease

af Zucca, Fabio A., Vanna, Renzo, Cupaioli, Francesca A., Bellei, Chiara, De Palma, Antonella, Di Silvestre, Dario, Mauri, Pierluigi, Grassi, Sara, Prinetti, Alessandro, Casella, Luigi, Sulzer, David, Zecca, Luigi
Udgivet i NPJ Parkinsons Dis (2018)

MHC-I expression renders catecholaminergic neurons susceptible to T-cell-mediated degeneration

af Cebrián, Carolina, Zucca, Fabio A., Mauri, Pierluigi, Steinbeck, Julius A., Studer, Lorenz, Scherzer, Clemens R., Kanter, Ellen, Budhu, Sadna, Mandelbaum, Jonathan, Vonsattel, Jean P., Zecca, Luigi, Loike, John D., Sulzer, David
Udgivet 2014

The role of iron and copper molecules in the neuronal vulnerability of locus coeruleus and substantia nigra during aging

af Zecca, Luigi, Stroppolo, Antonella, Gatti, Alberto, Tampellini, Davide, Toscani, Marco, Gallorini, Mario, Giaveri, Giuseppe, Arosio, Paolo, Santambrogio, Paolo, Fariello, Ruggero G., Karatekin, Erdem, Kleinman, Mark H., Turro, Nicholas, Hornykiewicz, Oleh, Zucca, Fabio A.
Udgivet 2004

A lysosome–plasma membrane–sphingolipid axis linking lysosomal storage to cell growth arrest

af Samarani, Maura, Loberto, Nicoletta, Soldà, Giulia, Straniero, Letizia, Asselta, Rosanna, Duga, Stefano, Lunghi, Giulia, Zucca, Fabio A., Mauri, Laura, Ciampa, Maria Grazia, Schiumarini, Domitilla, Bassi, Rosaria, Giussani, Paola, Chiricozzi, Elena, Prinetti, Alessandro, Aureli, Massimo, Sonnino, Sandro
Udgivet i FASEB J (2018)

Neuromelanin-sensitive MRI as a noninvasive proxy measure of dopamine function in the human brain

af Cassidy, Clifford M., Zucca, Fabio A., Girgis, Ragy R., Baker, Seth C., Weinstein, Jodi J., Sharp, Madeleine E., Bellei, Chiara, Valmadre, Alice, Vanegas, Nora, Kegeles, Lawrence S., Brucato, Gary, Kang, Un Jung, Sulzer, David, Zecca, Luigi, Abi-Dargham, Anissa, Horga, Guillermo
Udgivet i Proc Natl Acad Sci U S A (2019)

New melanic pigments in the human brain that accumulate in aging and block environmental toxic metals

af Zecca, Luigi, Bellei, Chiara, Costi, Patrizia, Albertini, Alberto, Monzani, Enrico, Casella, Luigi, Gallorini, Mario, Bergamaschi, Luigi, Moscatelli, Alberto, Turro, Nicholas J., Eisner, Melvin, Crippa, Pier Raimondo, Ito, Shosuke, Wakamatsu, Kazumasa, Bush, William D., Ward, Weslyn C., Simon, John D., Zucca, Fabio A.
Udgivet 2008

Neuromelanin activates microglia and induces degeneration of dopaminergic neurons: implications for progression of Parkinson's disease

af Zhang, Wei, Phillips, Kester, Wielgus, Albert R., Liu, Jie, Albertini, Alberto, Zucca, Fabio A., Faust, Rudolph, Qian, Steven Y., Miller, David S., Chignell, Colin F., Wilson, Belinda, Jackson-Lewis, Vernice, Przedborski, Serge, Joset, Danielle, Loike, John, Hong, Jau-Shyong, Sulzer, David, Zecca, Luigi
Udgivet 2009

Locus coeruleus imaging as a biomarker for noradrenergic dysfunction in neurodegenerative diseases

af Betts, Matthew J, Kirilina, Evgeniya, Otaduy, Maria C G, Ivanov, Dimo, Acosta-Cabronero, Julio, Callaghan, Martina F, Lambert, Christian, Cardenas-Blanco, Arturo, Pine, Kerrin, Passamonti, Luca, Loane, Clare, Keuken, Max C, Trujillo, Paula, Lüsebrink, Falk, Mattern, Hendrik, Liu, Kathy Y, Priovoulos, Nikos, Fliessbach, Klaus, Dahl, Martin J, Maaß, Anne, Madelung, Christopher F, Meder, David, Ehrenberg, Alexander J, Speck, Oliver, Weiskopf, Nikolaus, Dolan, Raymond, Inglis, Ben, Tosun, Duygu, Morawski, Markus, Zucca, Fabio A, Siebner, Hartwig R, Mather, Mara, Uludag, Kamil, Heinsen, Helmut, Poser, Benedikt A, Howard, Robert, Zecca, Luigi, Rowe, James B, Grinberg, Lea T, Jacobs, Heidi I L, Düzel, Emrah, Hämmerer, Dorothea
Udgivet i Brain (2019)