A lysosome–plasma membrane–sphingolipid axis linking lysosomal storage to cell growth arrest

Lysosomal accumulation of undegraded materials is a common feature of lysosomal storage diseases, neurodegenerative disorders, and the aging process. To better understand the role of lysosomal storage in the onset of cell damage, we used human fibroblasts loaded with sucrose as a model of lysosomal...

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Dades bibliogràfiques
Publicat a:FASEB J
Autors principals: Samarani, Maura, Loberto, Nicoletta, Soldà, Giulia, Straniero, Letizia, Asselta, Rosanna, Duga, Stefano, Lunghi, Giulia, Zucca, Fabio A., Mauri, Laura, Ciampa, Maria Grazia, Schiumarini, Domitilla, Bassi, Rosaria, Giussani, Paola, Chiricozzi, Elena, Prinetti, Alessandro, Aureli, Massimo, Sonnino, Sandro
Format: Artigo
Idioma:Inglês
Publicat: Federation of American Societies for Experimental Biology 2018
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6133699/
https://ncbi.nlm.nih.gov/pubmed/29746165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201701512RR
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