A lysosome–plasma membrane–sphingolipid axis linking lysosomal storage to cell growth arrest

Lysosomal accumulation of undegraded materials is a common feature of lysosomal storage diseases, neurodegenerative disorders, and the aging process. To better understand the role of lysosomal storage in the onset of cell damage, we used human fibroblasts loaded with sucrose as a model of lysosomal...

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Detalhes bibliográficos
Publicado no:FASEB J
Main Authors: Samarani, Maura, Loberto, Nicoletta, Soldà, Giulia, Straniero, Letizia, Asselta, Rosanna, Duga, Stefano, Lunghi, Giulia, Zucca, Fabio A., Mauri, Laura, Ciampa, Maria Grazia, Schiumarini, Domitilla, Bassi, Rosaria, Giussani, Paola, Chiricozzi, Elena, Prinetti, Alessandro, Aureli, Massimo, Sonnino, Sandro
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6133699/
https://ncbi.nlm.nih.gov/pubmed/29746165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201701512RR
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