The PPAR-γ agonist, darglitazone, restores acute inflammatory responses to cerebral hypoxia–ischemia in the diabetic ob/ob mouse

Por Kumari, Rashmi, Willing, Lisa B, Patel, Shyama D, Krady, J Kyle, Zavadoski, William J, Gibbs, E Michael, Vannucci, Susan J, Simpson, Ian A
Publicado em 2010

Polyomic profiling reveals significant hepatic metabolic alterations in glucagon-receptor (GCGR) knockout mice: implications on anti-glucagon therapies for diabetes

Por Yang, Jianxin, MacDougall, Margit L, McDowell, Michael T, Xi, Li, Wei, Ru, Zavadoski, William J, Molloy, Mark P, Baker, John D, Kuhn, Max, Cabrera, Over, Treadway, Judith L
Publicado em 2011

Modeling the Mechanism of Action of a DGAT1 Inhibitor Using a Causal Reasoning Platform

Por Enayetallah, Ahmed E., Ziemek, Daniel, Leininger, Michael T., Randhawa, Ranjit, Yang, Jianxin, Manion, Tara B., Mather, Dawn E., Zavadoski, William J., Kuhn, Max, Treadway, Judith L., des Etages, Shelly Ann G., Gibbs, E. Michael, Greene, Nigel, Steppan, Claire M.
Publicado em 2011

Discovery of PF-04620110, a Potent, Selective, and Orally Bioavailable Inhibitor of DGAT-1

Por Dow, Robert L., Li, Jian-Cheng, Pence, Michael P., Gibbs, E. Michael, LaPerle, Jennifer L., Litchfield, John, Piotrowski, David W., Munchhof, Michael J., Manion, Tara B., Zavadoski, William J., Walker, Gregory S., McPherson, R. Kirk, Tapley, Susan, Sugarman, Eliot, Guzman-Perez, Angel, DaSilva-Jardine, Paul
Publicado em 2011

A human APOC3 missense variant and monoclonal antibody accelerate apoC-III clearance and lower triglyceride-rich lipoprotein levels

Por Khetarpal, Sumeet A, Zeng, Xuemei, Millar, John S, Vitali, Cecilia, Somasundara, Amritha Varshini Hanasoge, Zanoni, Paolo, Landro, James A, Barucci, Nicole, Zavadoski, William J, Sun, Zhiyuan, de Haard, Hans, Toth, Ildikó V, Peloso, Gina M, Natarajan, Pradeep, Cuchel, Marina, Lund-Katz, Sissel, Phillips, Michael C, Tall, Alan R, Kathiresan, Sekar, DaSilva-Jardine, Paul, Yates, Nathan A, Rader, Daniel J
Publicado no Nat Med (2017)