A human APOC3 missense variant and monoclonal antibody accelerate apoC-III clearance and lower triglyceride-rich lipoprotein levels

Recent large-scale genetic sequencing efforts have identified rare coding variants in genes in the triglyceride-rich lipoprotein (TRL) clearance pathway that are protective against coronary heart disease (CHD), independently of LDL cholesterol (LDL-C) levels(1). Insight into the mechanisms of protec...

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Publicado no:Nat Med
Main Authors: Khetarpal, Sumeet A, Zeng, Xuemei, Millar, John S, Vitali, Cecilia, Somasundara, Amritha Varshini Hanasoge, Zanoni, Paolo, Landro, James A, Barucci, Nicole, Zavadoski, William J, Sun, Zhiyuan, de Haard, Hans, Toth, Ildikó V, Peloso, Gina M, Natarajan, Pradeep, Cuchel, Marina, Lund-Katz, Sissel, Phillips, Michael C, Tall, Alan R, Kathiresan, Sekar, DaSilva-Jardine, Paul, Yates, Nathan A, Rader, Daniel J
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5669375/
https://ncbi.nlm.nih.gov/pubmed/28825717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4390
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