Polyomic profiling reveals significant hepatic metabolic alterations in glucagon-receptor (GCGR) knockout mice: implications on anti-glucagon therapies for diabetes

BACKGROUND: Glucagon is an important hormone in the regulation of glucose homeostasis, particularly in the maintenance of euglycemia and prevention of hypoglycemia. In type 2 Diabetes Mellitus (T2DM), glucagon levels are elevated in both the fasted and postprandial states, which contributes to inapp...

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Main Authors: Yang, Jianxin, MacDougall, Margit L, McDowell, Michael T, Xi, Li, Wei, Ru, Zavadoski, William J, Molloy, Mark P, Baker, John D, Kuhn, Max, Cabrera, Over, Treadway, Judith L
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2011
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3130710/
https://ncbi.nlm.nih.gov/pubmed/21631939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-12-281
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