Novel Functional Complexity of Polycystin-1 by GPS Cleavage In Vivo: Role in Polycystic Kidney Disease

por Kurbegovic, Almira, Kim, Hyunho, Xu, Hangxue, Yu, Shengqiang, Cruanès, Julie, Maser, Robin L., Boletta, Alessandra, Trudel, Marie, Qian, Feng
Publicado em 2014

Cleavage of polycystin-1 requires the receptor for egg jelly domain and is disrupted by human autosomal-dominant polycystic kidney disease 1-associated mutations

por Qian, Feng, Boletta, Alessandra, Bhunia, Anil K., Xu, Hangxue, Liu, Lijuan, Ahrabi, Ali K., Watnick, Terry J., Zhou, Fang, Germino, Gregory G.
Publicado em 2002

Essential role of cleavage of Polycystin-1 at G protein-coupled receptor proteolytic site for kidney tubular structure

por Yu, Shengqiang, Hackmann, Karl, Gao, Jianggang, He, Xiaobing, Piontek, Klaus, García González, Miguel A., Menezes, Luis F., Xu, Hangxue, Germino, Gregory G., Zuo, Jian, Qian, Feng
Publicado em 2007

A novel model of autosomal recessive polycystic kidney questions the role of the Fibrocystin C-terminus in disease mechanism

por Outeda, Patricia, Menezes, Luis, Hartung, Erum A., Bridges, Stacey, Zhou, Fang, Zhu, Xianjun, Xu, Hangxue, Huang, Qiong, Yao, Qin, Qian, Feng, Germino, Gregory G, Watnick, Terry
Publicado no Kidney Int (2017)

Defective Glucose Metabolism in Polycystic Kidney Disease Identifies A Novel Therapeutic Paradigm

por Rowe, Isaline, Chiaravalli, Marco, Mannella, Valeria, Ulisse, Valeria, Quilici, Giacomo, Pema, Monika, Song, Xuewen W., Xu, Hangxue, Mari, Silvia, Qian, Feng, Pei, York, Musco, Giovanna, Boletta, Alessandra
Publicado no Nat Med (2013)

Ciliary membrane proteins traffic through the Golgi via a Rabep1/GGA1/Arl3-dependent mechanism

por Kim, Hyunho, Xu, Hangxue, Yao, Qin, Li, Weizhe, Huang, Qiong, Outeda, Patricia, Cebotaru, Valeriu, Chiaravalli, Marco, Boletta, Alessandra, Piontek, Klaus, Germino, Gregory G., Weinman, Edward J., Watnick, Terry, Qian, Feng
Publicado no Nat Commun (2014)

A Pkd1-Fbn1 Genetic Interaction Implicates TGF-β Signaling in the Pathogenesis of Vascular Complications in Autosomal Dominant Polycystic Kidney Disease

por Liu, Dongyan, Wang, Connie J., Judge, Daniel P., Halushka, Marc K., Ni, Jie, Habashi, Jennifer P., Moslehi, Javid, Bedja, Djahida, Gabrielson, Kathleen L., Xu, Hangxue, Qian, Feng, Huso, David, Dietz, Harry C., Germino, Gregory G., Watnick, Terry
Publicado em 2014