A Pkd1-Fbn1 Genetic Interaction Implicates TGF-β Signaling in the Pathogenesis of Vascular Complications in Autosomal Dominant Polycystic Kidney Disease

Autosomal dominant polycystic kidney disease (ADPKD) is a common cause of renal failure that is due to mutations in two genes, PKD1 and PKD2. Vascular complications, including aneurysms, are a well recognized feature of ADPKD, and a subgroup of families exhibits traits reminiscent of Marfan syndrome...

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Autori principali: Liu, Dongyan, Wang, Connie J., Judge, Daniel P., Halushka, Marc K., Ni, Jie, Habashi, Jennifer P., Moslehi, Javid, Bedja, Djahida, Gabrielson, Kathleen L., Xu, Hangxue, Qian, Feng, Huso, David, Dietz, Harry C., Germino, Gregory G., Watnick, Terry
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Nephrology 2014
Soggetti:
Basic Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3871766/
https://ncbi.nlm.nih.gov/pubmed/24071006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2012050486
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