Novel Functional Complexity of Polycystin-1 by GPS Cleavage In Vivo: Role in Polycystic Kidney Disease

door Kurbegovic, Almira, Kim, Hyunho, Xu, Hangxue, Yu, Shengqiang, Cruanès, Julie, Maser, Robin L., Boletta, Alessandra, Trudel, Marie, Qian, Feng
Gepubliceerd in 2014

Cleavage of polycystin-1 requires the receptor for egg jelly domain and is disrupted by human autosomal-dominant polycystic kidney disease 1-associated mutations

door Qian, Feng, Boletta, Alessandra, Bhunia, Anil K., Xu, Hangxue, Liu, Lijuan, Ahrabi, Ali K., Watnick, Terry J., Zhou, Fang, Germino, Gregory G.
Gepubliceerd in 2002

Essential role of cleavage of Polycystin-1 at G protein-coupled receptor proteolytic site for kidney tubular structure

door Yu, Shengqiang, Hackmann, Karl, Gao, Jianggang, He, Xiaobing, Piontek, Klaus, García González, Miguel A., Menezes, Luis F., Xu, Hangxue, Germino, Gregory G., Zuo, Jian, Qian, Feng
Gepubliceerd in 2007

A novel model of autosomal recessive polycystic kidney questions the role of the Fibrocystin C-terminus in disease mechanism

door Outeda, Patricia, Menezes, Luis, Hartung, Erum A., Bridges, Stacey, Zhou, Fang, Zhu, Xianjun, Xu, Hangxue, Huang, Qiong, Yao, Qin, Qian, Feng, Germino, Gregory G, Watnick, Terry
Gepubliceerd in Kidney Int (2017)

Defective Glucose Metabolism in Polycystic Kidney Disease Identifies A Novel Therapeutic Paradigm

door Rowe, Isaline, Chiaravalli, Marco, Mannella, Valeria, Ulisse, Valeria, Quilici, Giacomo, Pema, Monika, Song, Xuewen W., Xu, Hangxue, Mari, Silvia, Qian, Feng, Pei, York, Musco, Giovanna, Boletta, Alessandra
Gepubliceerd in Nat Med (2013)

Ciliary membrane proteins traffic through the Golgi via a Rabep1/GGA1/Arl3-dependent mechanism

door Kim, Hyunho, Xu, Hangxue, Yao, Qin, Li, Weizhe, Huang, Qiong, Outeda, Patricia, Cebotaru, Valeriu, Chiaravalli, Marco, Boletta, Alessandra, Piontek, Klaus, Germino, Gregory G., Weinman, Edward J., Watnick, Terry, Qian, Feng
Gepubliceerd in Nat Commun (2014)

A Pkd1-Fbn1 Genetic Interaction Implicates TGF-β Signaling in the Pathogenesis of Vascular Complications in Autosomal Dominant Polycystic Kidney Disease

door Liu, Dongyan, Wang, Connie J., Judge, Daniel P., Halushka, Marc K., Ni, Jie, Habashi, Jennifer P., Moslehi, Javid, Bedja, Djahida, Gabrielson, Kathleen L., Xu, Hangxue, Qian, Feng, Huso, David, Dietz, Harry C., Germino, Gregory G., Watnick, Terry
Gepubliceerd in 2014