Non-Linear and Flexible Regions of the Human Notch1 Extracellular Domain Revealed by High-Resolution Structural Studies

by Weisshuhn, Philip C., Sheppard, Devon, Taylor, Paul, Whiteman, Pat, Lea, Susan M., Handford, Penny A., Redfield, Christina
Published in Structure (2016)

Structural and functional dissection of the interplay between lipid and Notch binding by human Notch ligands

by Suckling, Richard J, Korona, Boguslawa, Whiteman, Pat, Chillakuri, Chandramouli, Holt, Laurie, Handford, Penny A, Lea, Susan M
Published in EMBO J (2017)

A Conserved Face of the Jagged/Serrate DSL Domain is Involved in Notch Trans-Activation and Cis-Inhibition

by Cordle, Jemima, Johnson, Steven, Tay, Joyce Zi Yan, Roversi, Pietro, Wilkin, Marian, Hernandez-Diaz, Beatriz, Shimizu, Hideyuki, Jensen, Sacha, Whiteman, Pat, Jin, Boquan, Redfield, Christina, Baron, Martin, Lea, Susan M., Handford, Penny A.
Published 2008

Molecular Basis for Jagged-1/Serrate Ligand Recognition by the Notch Receptor

by Whiteman, Pat, de Madrid, Beatriz Hernandez, Taylor, Paul, Li, Demin, Heslop, Rebecca, Viticheep, Nattnee, Tan, Joyce Zi, Shimizu, Hideyuki, Callaghan, Juliana, Masiero, Massimo, Li, Ji Liang, Banham, Alison H., Harris, Adrian L., Lea, Susan M., Redfield, Christina, Baron, Martin, Handford, Penny A.
Published 2013

Development of therapeutic anti-JAGGED1 antibodies for cancer therapy

by Masiero, Massimo, Li, Demin, Whiteman, Pat, Bentley, Carol, Greig, Jenny, Hassanali, Tasneem, Watts, Sarah, Stribbling, Stephen, Yates, Jenna, Bealing, Ellen, Li, Ji-Liang, Chillakuri, Chandramouli, Sheppard, Devon, Serres, Sébastien, Sarmiento-Soto, Manuel, Larkin, James, Sibson, Nicola R., Handford, Penny A., Harris, Adrian L., Banham, Alison H.
Published in Mol Cancer Ther (2019)

The CD46 and Jagged1 interaction is critical for human T helper 1 immunity

by Le Friec, Gaëlle, Sheppard, Devon, Whiteman, Pat, Karsten, Christian M., Shamoun, Salley Al-Tilib, Laing, Adam, Bugeon, Laurence, Dallman, Margaret J., Melchionna, Teresa, Chillakuri, Chandramouli, Smith, Richard A., Drouet, Christian, Couzi, Lionel, Fremeaux-Bacchi, Veronique, Köhl, Jörg, Waddington, Simon N., McDonnell, James M., Baker, Alastair, Handford, Penny A., Lea, Susan M., Kemper, Claudia
Published 2012