The CD46 and Jagged1 interaction is critical for human T helper 1 immunity

CD46 is a complement regulator with important immune-related roles. CD46 functions as a pathogen receptor and is a potent co-stimulator for the induction of interferon-γ (IFN-γ)-secreting T helper 1 (T(H)1) effector T cells and their subsequent switch into interleukin-10 (IL-10)-producing regulatory...

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Main Authors: Le Friec, Gaëlle, Sheppard, Devon, Whiteman, Pat, Karsten, Christian M., Shamoun, Salley Al-Tilib, Laing, Adam, Bugeon, Laurence, Dallman, Margaret J., Melchionna, Teresa, Chillakuri, Chandramouli, Smith, Richard A., Drouet, Christian, Couzi, Lionel, Fremeaux-Bacchi, Veronique, Köhl, Jörg, Waddington, Simon N., McDonnell, James M., Baker, Alastair, Handford, Penny A., Lea, Susan M., Kemper, Claudia
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3505834/
https://ncbi.nlm.nih.gov/pubmed/23086448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2454
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