PTH/PTHrP Receptor Signaling, Allostery, and Structures

nork Sutkeviciute, Ieva, Clark, Lisa J., White, Alex D., Gardella, Thomas J., Vilardaga, Jean-Pierre
Argitaratua izan da Trends Endocrinol Metab (2019)

Luminescence-activated nucleotide cyclase regulates spatial and temporal cAMP synthesis

nork Naim, Nyla, White, Alex D., Reece, Jeff M., Wankhede, Mamta, Zhang, Xuefeng, Vilardaga, Jean-Pierre, Altschuler, Daniel L.
Argitaratua izan da J Biol Chem (2019)

Use of Backbone Modification to Enlarge the Spatiotemporal Diversity of Parathyroid Hormone Receptor-1 Signaling via Biased Agonism

nork Liu, Shi, Jean-Alphonse, Frederic G., White, Alex D., Wootten, Denise, Sexton, Patrick M., Gardella, Thomas J., Vilardaga, Jean-Pierre, Gellman, Samuel H.
Argitaratua izan da J Am Chem Soc (2019)

Ca(2+) allostery in PTH-receptor signaling

nork White, Alex D., Fang, Fei, Jean-Alphonse, Frédéric G., Clark, Lisa J., An, Hyun-Jung, Liu, Hongda, Zhao, Yang, Reynolds, Shelley L., Lee, Sihoon, Xiao, Kunhong, Sutkeviciute, Ieva, Vilardaga, Jean-Pierre
Argitaratua izan da Proc Natl Acad Sci U S A (2019)

G(q/11)-dependent regulation of endosomal cAMP generation by parathyroid hormone class B GPCR

nork White, Alex D., Jean-Alphonse, Frederic G., Fang, Fei, Peña, Karina A., Liu, Shi, König, Gabriele M., Inoue, Asuka, Aslanoglou, Despoina, Gellman, Samuel H., Kostenis, Evi, Xiao, Kunhong, Vilardaga, Jean-Pierre
Argitaratua izan da Proc Natl Acad Sci U S A (2020)

Allosteric interactions in the parathyroid hormone GPCR–arrestin complex formation

nork Clark, Lisa J., Krieger, James, White, Alex D., Bondarenko, Vasyl, Lei, Saifei, Fang, Fei, Lee, Ji Young, Doruker, Pemra, Böttke, Thore, Jean-Alphonse, Frederic, Tang, Pei, Gardella, Thomas J., Xiao, Kunhong, Sutkeviciute, Ieva, Coin, Irene, Bahar, Ivet, Vilardaga, Jean-Pierre
Argitaratua izan da Nat Chem Biol (2020)

PTH Hypersecretion Triggered by a GABA(B1) and Ca(2+)-sensing Receptor Heterocomplex in Hyperparathyroidism

nork Chang, Wenhan, Tu, Chia-Ling, Jean-Alphonse, Frederic, Herberger, Amanda, Cheng, Zhiqiang, Hwong, Jenna, Ho, Hanson, Li, Alfred, Wang, Dawei, Liu, Hongda, White, Alex D., Suh, Insoo, Shen, Wen, Duh, Quan-Yang, Khanafshar, Elham, Shoback, Dolores M., Xiao, Kunhong, Vilardaga, Jean-Pierre
Argitaratua izan da Nat Metab (2020)

Structure and dynamics of the active human parathyroid hormone receptor-1

nork Zhao, Li-Hua, Ma, Shanshan, Sutkeviciute, Ieva, Shen, Dan-Dan, Zhou, X. Edward, de Waal, Parker W., Li, Chen-Yao, Kang, Yanyong, Clark, Lisa J., Jean-Alphonse, Frederic G., White, Alex D., Yang, Dehua, Dai, Antao, Cai, Xiaoqing, Chen, Jian, Li, Cong, Jiang, Yi, Watanabe, Tomoyuki, Gardella, Thomas J., Melcher, Karsten, Wang, Ming-Wei, Vilardaga, Jean-Pierre, Xu, H. Eric, Zhang, Yan
Argitaratua izan da Science (2019)