Allosteric interactions in the parathyroid hormone GPCR–arrestin complex formation

Peptide ligands of class B G protein-coupled receptors (GPCRs) act via a two-step binding process, but the essential mechanisms that link their extracellular binding to intracellular receptor–arrestin interactions are not fully understood. Using NMR, crosslinking coupled to mass spectrometry, signal...

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Bibliografiska uppgifter
I publikationen:Nat Chem Biol
Huvudupphovsmän: Clark, Lisa J., Krieger, James, White, Alex D., Bondarenko, Vasyl, Lei, Saifei, Fang, Fei, Lee, Ji Young, Doruker, Pemra, Böttke, Thore, Jean-Alphonse, Frederic, Tang, Pei, Gardella, Thomas J., Xiao, Kunhong, Sutkeviciute, Ieva, Coin, Irene, Bahar, Ivet, Vilardaga, Jean-Pierre
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2020
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7502484/
https://ncbi.nlm.nih.gov/pubmed/32632293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-020-0567-0
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