PTH/PTHrP Receptor Signaling, Allostery, and Structures

Por Sutkeviciute, Ieva, Clark, Lisa J., White, Alex D., Gardella, Thomas J., Vilardaga, Jean-Pierre
Publicado no Trends Endocrinol Metab (2019)

Luminescence-activated nucleotide cyclase regulates spatial and temporal cAMP synthesis

Por Naim, Nyla, White, Alex D., Reece, Jeff M., Wankhede, Mamta, Zhang, Xuefeng, Vilardaga, Jean-Pierre, Altschuler, Daniel L.
Publicado no J Biol Chem (2019)

Use of Backbone Modification to Enlarge the Spatiotemporal Diversity of Parathyroid Hormone Receptor-1 Signaling via Biased Agonism

Por Liu, Shi, Jean-Alphonse, Frederic G., White, Alex D., Wootten, Denise, Sexton, Patrick M., Gardella, Thomas J., Vilardaga, Jean-Pierre, Gellman, Samuel H.
Publicado no J Am Chem Soc (2019)

Ca(2+) allostery in PTH-receptor signaling

Por White, Alex D., Fang, Fei, Jean-Alphonse, Frédéric G., Clark, Lisa J., An, Hyun-Jung, Liu, Hongda, Zhao, Yang, Reynolds, Shelley L., Lee, Sihoon, Xiao, Kunhong, Sutkeviciute, Ieva, Vilardaga, Jean-Pierre
Publicado no Proc Natl Acad Sci U S A (2019)

G(q/11)-dependent regulation of endosomal cAMP generation by parathyroid hormone class B GPCR

Por White, Alex D., Jean-Alphonse, Frederic G., Fang, Fei, Peña, Karina A., Liu, Shi, König, Gabriele M., Inoue, Asuka, Aslanoglou, Despoina, Gellman, Samuel H., Kostenis, Evi, Xiao, Kunhong, Vilardaga, Jean-Pierre
Publicado no Proc Natl Acad Sci U S A (2020)

Allosteric interactions in the parathyroid hormone GPCR–arrestin complex formation

Por Clark, Lisa J., Krieger, James, White, Alex D., Bondarenko, Vasyl, Lei, Saifei, Fang, Fei, Lee, Ji Young, Doruker, Pemra, Böttke, Thore, Jean-Alphonse, Frederic, Tang, Pei, Gardella, Thomas J., Xiao, Kunhong, Sutkeviciute, Ieva, Coin, Irene, Bahar, Ivet, Vilardaga, Jean-Pierre
Publicado no Nat Chem Biol (2020)

PTH Hypersecretion Triggered by a GABA(B1) and Ca(2+)-sensing Receptor Heterocomplex in Hyperparathyroidism

Por Chang, Wenhan, Tu, Chia-Ling, Jean-Alphonse, Frederic, Herberger, Amanda, Cheng, Zhiqiang, Hwong, Jenna, Ho, Hanson, Li, Alfred, Wang, Dawei, Liu, Hongda, White, Alex D., Suh, Insoo, Shen, Wen, Duh, Quan-Yang, Khanafshar, Elham, Shoback, Dolores M., Xiao, Kunhong, Vilardaga, Jean-Pierre
Publicado no Nat Metab (2020)

Structure and dynamics of the active human parathyroid hormone receptor-1

Por Zhao, Li-Hua, Ma, Shanshan, Sutkeviciute, Ieva, Shen, Dan-Dan, Zhou, X. Edward, de Waal, Parker W., Li, Chen-Yao, Kang, Yanyong, Clark, Lisa J., Jean-Alphonse, Frederic G., White, Alex D., Yang, Dehua, Dai, Antao, Cai, Xiaoqing, Chen, Jian, Li, Cong, Jiang, Yi, Watanabe, Tomoyuki, Gardella, Thomas J., Melcher, Karsten, Wang, Ming-Wei, Vilardaga, Jean-Pierre, Xu, H. Eric, Zhang, Yan
Publicado no Science (2019)