PTH/PTHrP Receptor Signaling, Allostery, and Structures

von Sutkeviciute, Ieva, Clark, Lisa J., White, Alex D., Gardella, Thomas J., Vilardaga, Jean-Pierre
Veröffentlicht in Trends Endocrinol Metab (2019)

Luminescence-activated nucleotide cyclase regulates spatial and temporal cAMP synthesis

von Naim, Nyla, White, Alex D., Reece, Jeff M., Wankhede, Mamta, Zhang, Xuefeng, Vilardaga, Jean-Pierre, Altschuler, Daniel L.
Veröffentlicht in J Biol Chem (2019)

Use of Backbone Modification to Enlarge the Spatiotemporal Diversity of Parathyroid Hormone Receptor-1 Signaling via Biased Agonism

von Liu, Shi, Jean-Alphonse, Frederic G., White, Alex D., Wootten, Denise, Sexton, Patrick M., Gardella, Thomas J., Vilardaga, Jean-Pierre, Gellman, Samuel H.
Veröffentlicht in J Am Chem Soc (2019)

Ca(2+) allostery in PTH-receptor signaling

von White, Alex D., Fang, Fei, Jean-Alphonse, Frédéric G., Clark, Lisa J., An, Hyun-Jung, Liu, Hongda, Zhao, Yang, Reynolds, Shelley L., Lee, Sihoon, Xiao, Kunhong, Sutkeviciute, Ieva, Vilardaga, Jean-Pierre
Veröffentlicht in Proc Natl Acad Sci U S A (2019)

G(q/11)-dependent regulation of endosomal cAMP generation by parathyroid hormone class B GPCR

von White, Alex D., Jean-Alphonse, Frederic G., Fang, Fei, Peña, Karina A., Liu, Shi, König, Gabriele M., Inoue, Asuka, Aslanoglou, Despoina, Gellman, Samuel H., Kostenis, Evi, Xiao, Kunhong, Vilardaga, Jean-Pierre
Veröffentlicht in Proc Natl Acad Sci U S A (2020)

Allosteric interactions in the parathyroid hormone GPCR–arrestin complex formation

von Clark, Lisa J., Krieger, James, White, Alex D., Bondarenko, Vasyl, Lei, Saifei, Fang, Fei, Lee, Ji Young, Doruker, Pemra, Böttke, Thore, Jean-Alphonse, Frederic, Tang, Pei, Gardella, Thomas J., Xiao, Kunhong, Sutkeviciute, Ieva, Coin, Irene, Bahar, Ivet, Vilardaga, Jean-Pierre
Veröffentlicht in Nat Chem Biol (2020)

PTH Hypersecretion Triggered by a GABA(B1) and Ca(2+)-sensing Receptor Heterocomplex in Hyperparathyroidism

von Chang, Wenhan, Tu, Chia-Ling, Jean-Alphonse, Frederic, Herberger, Amanda, Cheng, Zhiqiang, Hwong, Jenna, Ho, Hanson, Li, Alfred, Wang, Dawei, Liu, Hongda, White, Alex D., Suh, Insoo, Shen, Wen, Duh, Quan-Yang, Khanafshar, Elham, Shoback, Dolores M., Xiao, Kunhong, Vilardaga, Jean-Pierre
Veröffentlicht in Nat Metab (2020)

Structure and dynamics of the active human parathyroid hormone receptor-1

von Zhao, Li-Hua, Ma, Shanshan, Sutkeviciute, Ieva, Shen, Dan-Dan, Zhou, X. Edward, de Waal, Parker W., Li, Chen-Yao, Kang, Yanyong, Clark, Lisa J., Jean-Alphonse, Frederic G., White, Alex D., Yang, Dehua, Dai, Antao, Cai, Xiaoqing, Chen, Jian, Li, Cong, Jiang, Yi, Watanabe, Tomoyuki, Gardella, Thomas J., Melcher, Karsten, Wang, Ming-Wei, Vilardaga, Jean-Pierre, Xu, H. Eric, Zhang, Yan
Veröffentlicht in Science (2019)