New directions using reporter enzyme fluorescence (REF) as a tuberculosis diagnostic platform

Por Sule, Preeti, Tilvawala, Ronak, Behinaein, Parnia, Walkup, Grant K., Cirillo, Jeffrey D.
Publicado no Tuberculosis (Edinb) (2016)

Secreted Gaussia princeps Luciferase as a Reporter of Escherichia coli Replication in a Mouse Tissue Cage Model of Infection

Por Liu, Mingyu, Blinn, Christina, McLeod, Sarah M., Wiseman, John W., Newman, Joseph V., Fisher, Stewart L., Walkup, Grant K.
Publicado em 2014

Avibactam is a covalent, reversible, non–β-lactam β-lactamase inhibitor

Por Ehmann, David E., Jahić, Haris, Ross, Philip L., Gu, Rong-Fang, Hu, Jun, Kern, Gunther, Walkup, Grant K., Fisher, Stewart L.
Publicado em 2012

Novel Bacterial NAD(+)-Dependent DNA Ligase Inhibitors with Broad-Spectrum Activity and Antibacterial Efficacy In Vivo

Por Mills, Scott D., Eakin, Ann E., Buurman, Ed T., Newman, Joseph V., Gao, Ning, Huynh, Hoan, Johnson, Kenneth D., Lahiri, Sushmita, Shapiro, Adam B., Walkup, Grant K., Yang, Wei, Stokes, Suzanne S.
Publicado em 2011

Inhibition of Neisseria gonorrhoeae Type II Topoisomerases by the Novel Spiropyrimidinetrione AZD0914

Por Kern, Gunther, Palmer, Tiffany, Ehmann, David E., Shapiro, Adam B., Andrews, Beth, Basarab, Gregory S., Doig, Peter, Fan, Jun, Gao, Ning, Mills, Scott D., Mueller, John, Sriram, Shubha, Thresher, Jason, Walkup, Grant K.
Publicado no J Biol Chem (2015)

Kinetics of Avibactam Inhibition against Class A, C, and D β-Lactamases

Por Ehmann, David E., Jahić, Haris, Ross, Philip L., Gu, Rong-Fang, Hu, Jun, Durand-Réville, Thomas F., Lahiri, Sushmita, Thresher, Jason, Livchak, Stephania, Gao, Ning, Palmer, Tiffany, Walkup, Grant K., Fisher, Stewart L.
Publicado em 2013

Discovery of Inhibitors of 4′-Phosphopantetheine Adenylyltransferase (PPAT) To Validate PPAT as a Target for Antibacterial Therapy

Por de Jonge, Boudewijn L. M., Walkup, Grant K., Lahiri, Sushmita D., Huynh, Hoan, Neckermann, Georg, Utley, Luke, Nash, Tory J., Brock, Jesse, San Martin, Maryann, Kutschke, Amy, Johnstone, Michele, Laganas, Valerie, Hajec, Laurel, Gu, Rong-Fang, Ni, Haihong, Chen, Brendan, Hutchings, Kim, Holt, Elise, McKinney, David, Gao, Ning, Livchak, Stephania, Thresher, Jason
Publicado em 2013

Responding to the challenge of untreatable gonorrhea: ETX0914, a first-in-class agent with a distinct mechanism-of-action against bacterial Type II topoisomerases

Por Basarab, Gregory S., Kern, Gunther H., McNulty, John, Mueller, John P., Lawrence, Kenneth, Vishwanathan, Karthick, Alm, Richard A., Barvian, Kevin, Doig, Peter, Galullo, Vincent, Gardner, Humphrey, Gowravaram, Madhusudhan, Huband, Michael, Kimzey, Amy, Morningstar, Marshall, Kutschke, Amy, Lahiri, Sushmita D., Perros, Manos, Singh, Renu, Schuck, Virna J. A., Tommasi, Ruben, Walkup, Grant, Newman, Joseph V.
Publicado no Sci Rep (2015)

Corrigendum: Responding to the challenge of untreatable gonorrhea: ETX0914, a first-in-class agent with a distinct mechanism-of-action against bacterial Type II topoisomerases

Por Basarab, Gregory S., Kern, Gunther H., McNulty, John, Mueller, John P., Lawrence, Kenneth, Vishwanathan, Karthick, Alm, Richard A., Barvian, Kevin, Doig, Peter, Galullo, Vincent, Gardner, Humphrey, Gowravaram, Madhusudhan, Huband, Michael, Kimzey, Amy, Morningstar, Marshall, Kutschke, Amy, Lahiri, Sushmita D., Perros, Manos, Singh, Renu, Schuck, Virna J. A., Tommasi, Ruben, Walkup, Grant, Newman, Joseph V.
Publicado no Sci Rep (2015)

Pyrrolamide DNA Gyrase Inhibitors: Fragment-Based Nuclear Magnetic Resonance Screening To Identify Antibacterial Agents

Por Eakin, Ann E., Green, Oluyinka, Hales, Neil, Walkup, Grant K., Bist, Shanta, Singh, Alok, Mullen, George, Bryant, Joanna, Embrey, Kevin, Gao, Ning, Breeze, Alex, Timms, Dave, Andrews, Beth, Uria-Nickelsen, Maria, Demeritt, Julie, Loch, James T., Hull, Ken, Blodgett, April, Illingworth, Ruth N., Prince, Bryan, Boriack-Sjodin, P. Ann, Hauck, Sheila, MacPherson, Lawrence J., Ni, Haihong, Sherer, Brian
Publicado em 2012

Translating slow-binding inhibition kinetics into cellular and in vivo effects

Por Walkup, Grant K., You, Zhiping, Ross, Philip L., Allen, Eleanor K. H., Daryaee, Fereidoon, Hale, Michael R., O’Donnell, John, Ehmann, David E., Schuck, Virna J. A., Buurman, Ed T., Choy, Allison L., Hajec, Laurel, Murphy-Benenato, Kerry, Marone, Valerie, Patey, Sara A., Grosser, Lena A., Johnstone, Michele, Walker, Stephen G., Tonge, Peter J., Fisher, Stewart L.
Publicado no Nat Chem Biol (2015)