Novel Bacterial NAD(+)-Dependent DNA Ligase Inhibitors with Broad-Spectrum Activity and Antibacterial Efficacy In Vivo

DNA ligases are indispensable enzymes playing a critical role in DNA replication, recombination, and repair in all living organisms. Bacterial NAD(+)-dependent DNA ligase (LigA) was evaluated for its potential as a broad-spectrum antibacterial target. A novel class of substituted adenosine analogs w...

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Detalhes bibliográficos
Main Authors: Mills, Scott D., Eakin, Ann E., Buurman, Ed T., Newman, Joseph V., Gao, Ning, Huynh, Hoan, Johnson, Kenneth D., Lahiri, Sushmita, Shapiro, Adam B., Walkup, Grant K., Yang, Wei, Stokes, Suzanne S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2011
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Mechanisms of Action: Physiological Effects
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3067096/
https://ncbi.nlm.nih.gov/pubmed/21189350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01181-10
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