In Vitro Validation of Acetyltransferase Activity of GlmU as an Antibacterial Target in Haemophilus influenzae

GlmU is a bifunctional enzyme that is essential for bacterial growth, converting d-glucosamine 1-phosphate into UDP-GlcNAc via acetylation and subsequent uridyl transfer. A biochemical screen of AstraZeneca's compound library using GlmU of Escherichia coli identified novel sulfonamide inhibitor...

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Main Authors: Buurman, Ed T., Andrews, Beth, Gao, Ning, Hu, Jun, Keating, Thomas A., Lahiri, Sushmita, Otterbein, Ludovic R., Patten, Arthur D., Stokes, Suzanne S., Shapiro, Adam B.
格式: Artigo
語言:Inglês
出版: American Society for Biochemistry and Molecular Biology 2011
主題:
Enzymology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3220512/
https://ncbi.nlm.nih.gov/pubmed/21984832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.274068
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