In Vitro Validation of Acetyltransferase Activity of GlmU as an Antibacterial Target in Haemophilus influenzae

GlmU is a bifunctional enzyme that is essential for bacterial growth, converting d-glucosamine 1-phosphate into UDP-GlcNAc via acetylation and subsequent uridyl transfer. A biochemical screen of AstraZeneca's compound library using GlmU of Escherichia coli identified novel sulfonamide inhibitor...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Buurman, Ed T., Andrews, Beth, Gao, Ning, Hu, Jun, Keating, Thomas A., Lahiri, Sushmita, Otterbein, Ludovic R., Patten, Arthur D., Stokes, Suzanne S., Shapiro, Adam B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3220512/
https://ncbi.nlm.nih.gov/pubmed/21984832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.274068
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados