The ever unfolding story of cAMP signaling in trypanosomatids: vive la difference!

Por Tagoe, Daniel N. A., Kalejaiye, Titilola D., de Koning, Harry P.
Publicado no Front Pharmacol (2015)

Pyrimidine Biosynthesis Is Not an Essential Function for Trypanosoma brucei Bloodstream Forms

Por Ali, Juma A. M., Tagoe, Daniel N. A., Munday, Jane C., Donachie, Anne, Morrison, Liam J., de Koning, Harry P.
Publicado em 2013

Reduced Mitochondrial Membrane Potential Is a Late Adaptation of Trypanosoma brucei brucei to Isometamidium Preceded by Mutations in the γ Subunit of the F(1)F(o)-ATPase

Por Eze, Anthonius A., Gould, Matthew K., Munday, Jane C., Tagoe, Daniel N. A., Stelmanis, Valters, Schnaufer, Achim, De Koning, Harry P.
Publicado no PLoS Negl Trop Dis (2016)

Functional and genetic evidence that nucleoside transport is highly conserved in Leishmania species: Implications for pyrimidine-based chemotherapy

Por Alzahrani, Khalid J.H., Ali, Juma A.M., Eze, Anthonius A., Looi, Wan Limm, Tagoe, Daniel N.A., Creek, Darren J., Barrett, Michael P., de Koning, Harry P.
Publicado no Int J Parasitol Drugs Drug Resist (2017)

Cyclic AMP Effectors in African Trypanosomes Revealed by Genome-Scale RNA Interference Library Screening for Resistance to the Phosphodiesterase Inhibitor CpdA

Por Gould, Matthew K., Bachmaier, Sabine, Ali, Juma A. M., Alsford, Sam, Tagoe, Daniel N. A., Munday, Jane C., Schnaufer, Achim C., Horn, David, Boshart, Michael, de Koning, Harry P.
Publicado em 2013

Functional analysis of drug resistance‐associated mutations in the T rypanosoma brucei adenosine transporter 1 (TbAT1) and the proposal of a structural model for the protein

Por Munday, Jane C., Tagoe, Daniel N. A., Eze, Anthonius A., Krezdorn, Jessica A. M., Rojas López, Karla E., Alkhaldi, Abdulsalam A. M., McDonald, Fiona, Still, Jennifer, Alzahrani, Khalid J., Settimo, Luca, De Koning, Harry P.
Publicado no Mol Microbiol (2015)

Targeting a Subpocket in Trypanosoma brucei Phosphodiesterase B1 (TbrPDEB1) Enables the Structure-Based Discovery of Selective Inhibitors with Trypanocidal Activity

Por Blaazer, Antoni R., Singh, Abhimanyu K., de Heuvel, Erik, Edink, Ewald, Orrling, Kristina M., Veerman, Johan J. N., van den Bergh, Toine, Jansen, Chimed, Balasubramaniam, Erin, Mooij, Wouter J., Custers, Hans, Sijm, Maarten, Tagoe, Daniel N. A., Kalejaiye, Titilola D., Munday, Jane C., Tenor, Hermann, Matheeussen, An, Wijtmans, Maikel, Siderius, Marco, de Graaf, Chris, Maes, Louis, de Koning, Harry P., Bailey, David S., Sterk, Geert Jan, de Esch, Iwan J. P., Brown, David G., Leurs, Rob
Publicado no J Med Chem (2018)